Members
Overall Objectives
Application Domains
New Software and Platforms
New Results
Partnerships and Cooperations
Dissemination
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Section: Partnerships and Cooperations

National Initiatives

ANR

In 2014, NANO-D had funding from two ANR programs:

PEPS

Sergei Grudinin participates in the Cryo-CA PEPS project. Cryo-CA (Computational algorithms for biomolecular structure determination by cryo-electron microscopy) is a 2-years project, supported by the Projets Exploratoires Pluridisciplinaires (PEPS) program in the panel Bio-Maths-Info provided by CNRS (French National Centre for Scientific Research). The project started on the 01/09/2012. Its main goal is to develop computational algorithms for cryo-electron microscopy (cryo-EM).

The partners of the Cryo-CA project are: Inria Nancy / Team Orpailleur (David Ritchie); Inria Grenoble / Team NANO-D (Sergei Grudinin); and INSERM IGBMC/ Team Integrated structural Biology (Annick Dejaegere, Patrick Schultz, and Benjamin Schwarz).

The main scientific aim of this cross-disciplinary project is to develop computational algorithms to help experimentalists and molecular modelers to solve more rapidly and accurately the structures of macromolecular complexes using cryo-electron microscopy (cryo- EM) and integrative structural biomolecular modeling techniques. More specifically, this PEPS initiative aims to address two important challenges in single particle cryo-EM, namely particle picking and multi-dimensional structure fitting. In the longer term, a further driving aim of this project is to develop strong collaborations amongst the participating teams to position ourselves for a larger project proposal to ANR or ERC.